Genetic variation in interleukin-17 receptor A is functionally associated with chronic rejection after lung transplantation
D Ruttens, E Wauters, M Kiciński, SE Verleden… - The Journal of Heart and …, 2013 - Elsevier
Background Chronic rejection is the major cause of morbidity and mortality after lung
transplantation. Interleukin (IL)-17–producing cells, inducers of airway neutrophilia, play a
prominent role in chronic rejection. Methods We investigated the association between
genetic variants in the IL-17/IL-23 pathway and outcome after lung transplantation. Six
genetic variants in IL-17 and IL-23 receptor genes were genotyped in 497 lung transplant
patients. Associations with chronic rejection, death, airway and systemic inflammatory …
transplantation. Interleukin (IL)-17–producing cells, inducers of airway neutrophilia, play a
prominent role in chronic rejection. Methods We investigated the association between
genetic variants in the IL-17/IL-23 pathway and outcome after lung transplantation. Six
genetic variants in IL-17 and IL-23 receptor genes were genotyped in 497 lung transplant
patients. Associations with chronic rejection, death, airway and systemic inflammatory …
